Premium
Treatment of a mobile intracardiac thrombus using ultra‐slow low‐dose tissue plasminogen activator in combination with heparin
Author(s) -
Polen C. B.,
Mullins Busch H. N.,
Ratliff P. D.
Publication year - 2018
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/jcpt.12626
Subject(s) - intracardiac injection , heparin , medicine , pulmonary embolism , thrombus , tissue plasminogen activator , cardiology , right heart
Summary What is known and objective Free‐floating thrombi in the right heart occur in a subset of patients with pulmonary embolism with high rates of mortality if untreated. Treatment of choice is controversial and likely patient specific as studies have failed to consistently show a significant difference in mortality between options. Case summary We present a case of a 45‐year‐old female with a mobile right heart thrombus treated with ultra‐slow, low‐dose t‐ PA infusion in combination with heparin. What is new and conclusion Ultra‐slow, low‐dose infusion of t‐ PA may be an option for treatment of mobile intracardiac thrombi.