Premium
Good for the lung but bad for the liver? Garlic‐induced hepatotoxicity following liver transplantation
Author(s) -
Shaikh S. A.,
Tischer S.,
Choi E. K.,
Fontana R. J.
Publication year - 2017
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/jcpt.12558
Subject(s) - liver transplantation , medicine , lung , liver toxicity , lung transplantation , gastroenterology , transplantation , toxicity
Summary What is known and objective Limited data exist surrounding the metabolism and safety of garlic supplements. Case description A patient with a history of hepatopulmonary syndrome ( HPS ) and orthotopic liver transplantation was admitted to our surgery transplant service with severe hypoxaemia. The patient was started on high‐dose Garlicin Cardio ® ( Allium sativum ) for HPS and soon after had elevated liver function tests. Garlicin Cardio ® was discontinued and liver enzymes normalized. A liver biopsy revealed mild periportal cholestatic reaction suggesting potential drug‐induced aetiology. What is new and conclusion This is the first description of liver injury secondary to garlic supplementation. Therefore, this garlic supplement should be listed as a potential cause of acute drug‐induced liver injury.