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A case of Fanconi syndrome due to a deferasirox overdose and a trial of plasmapheresis
Author(s) -
Shah L.,
Powell J. L.,
Zaritsky J. J.
Publication year - 2017
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/jcpt.12553
Subject(s) - plasmapheresis , deferasirox , medicine , pediatrics , immunology , antibody , thalassemia
Summary What is known and objective Deferasirox has nephrotoxic effects in the context of chronic therapy. This case report illustrates proximal tubular dysfunction (Fanconi syndrome) due to an acute deferasirox overdose. Case description In response, we trialled plasmapheresis to eliminate the drug. Deferasirox levels were obtained in the context of three rounds of plasmapheresis. Given the half‐life model of decay, we concluded that plasmapheresis may not have been successful. The patient ultimately recovered normal tubular function after 2 months. What is new and conclusion This report is the first to describe acute deferasirox‐induced nephrotoxicity, and the application of plasmapheresis that, ultimately, did not change the typical time to recovery.