Premium
Pulsatile crizotinib treatment for brain metastasis in a patient with non‐small‐cell lung cancer
Author(s) -
Wang S.,
Chen J.,
Xie Z.,
Xia L.,
Luo W.,
Li J.,
Li Q.,
Yang Z.
Publication year - 2017
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/jcpt.12550
Subject(s) - crizotinib , medicine , anaplastic lymphoma kinase , lung cancer , brain metastasis , ceritinib , oncology , tyrosine kinase inhibitor , metastasis , central nervous system , cancer , malignant pleural effusion
Summary What is known and objective Anaplastic lymphoma kinase ( ALK )‐rearranged non‐small‐cell lung cancer ( NSCLC ) is a distinct subtype with patients showing peculiar clinicopathological features and dramatic responses to the ALK tyrosine kinase inhibitor crizotinib. Patients with this cancer variant have a dismal prognosis and limited treatment options when it has progressed to intracranial metastasis because of inadequate drug penetration into the central nervous system ( CNS ). Factors associated with response to TKI therapy have been reported to include pharmacokinetic and biodynamic resistance phenomena. Case description In our NSCLC patient with multiple intracranial metastases, we administered high‐dose pulsatile crizotinib therapy (1000 mg/d) on a one‐day‐on/one‐day‐off basis. A significant central nervous system ( CNS ) response was achieved, and time to neurological progression was prolonged to 6 months. What is new and conclusion High‐dose pulsatile therapy may be an effective dosing strategy for crizotinib in NSCLC showing progression to metastasis in the brain.