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Cure with ledipasvir/sofosbuvir for chronic hepatitis C virus in an individual with gastric bypass
Author(s) -
Johnson S. W.,
Teachey A. L.,
Valanejad S. M.,
Griffin S. M.,
Weber S. F.
Publication year - 2017
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/jcpt.12547
Subject(s) - sofosbuvir , ledipasvir , medicine , virology , hepatitis c virus , gastroenterology , gastric bypass , chronic hepatitis , hepatitis c , virus , ribavirin , weight loss , obesity
Summary What is known and objective The impact of gastric bypass surgery on the pharmacokinetics of various medications has been reported. Presently, no data exist for the treatment of chronic hepatitis C virus with ledipasvir/sofosbuvir ( LDV / SOF ) in an individual with a history of gastric bypass. Case description We report the successful cure of an individual who was treated with LDV / SOF who had a history of gastric bypass. The patient tolerated LDV / SOF well while only experiencing a minor headache. What is new and conclusion Ledipasvir/sofosbuvir treatment may still be effective in those with a history of gastric bypass surgery.