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Pharmacist intervention to detect drug adverse events on admission to the emergency department: Two case reports of neuroleptic malignant syndrome
Author(s) -
Leenhardt F.,
Perier D.,
Pinzani V.,
Giraud I.,
Villiet M.,
CastetNicolas A.,
Gourhant V.,
Breuker C.
Publication year - 2017
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/jcpt.12531
Subject(s) - neuroleptic malignant syndrome , medicine , antipsychotic drug , adverse effect , emergency department , intervention (counseling) , clozapine , clinical pharmacy , drug , antipsychotic , drug reaction , pharmacist , emergency medicine , adverse drug reaction , medical emergency , schizophrenia (object oriented programming) , psychiatry , pediatrics , pharmacy , family medicine
Summary What is known and objective Neuroleptic malignant syndrome ( NMS ) is a rare but severe adverse effect of antipsychotic drugs. Case description We report two cases of NMS highlighted by clinical pharmacists in an emergency unit during summer. One of them was fatal. Medication reconciliation processes performed at admission identified treatment with loxapine for one of them and with loxapine and clozapine for the other. Interview of the patients highlighted clinical symptoms suggesting NMS , allowing the pharmacists to alert the medical team. What is new and conclusion Adverse drug events may be severe and clinical pharmacists in emergency departments can help to detect them.