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Anterior ST‐elevation myocardial infarction induced by rituximab infusion: A case report and review of the literature
Author(s) -
Sharif K.,
Watad A.,
Bragazzi N. L.,
Asher E.,
Abu Much A.,
Horowitz Y.,
Lidar M.,
Shoenfeld Y.,
Amital H.
Publication year - 2017
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/jcpt.12522
Subject(s) - rituximab , medicine , thrombocytopenic purpura , myocardial infarction , rheumatoid arthritis , vasculitis , thrombotic thrombocytopenic purpura , cardiology , adverse effect , cd20 , surgery , disease , lymphoma , platelet
Summary What is known and objectives Rituximab is a chimeric monoclonal anti‐CD20 antibody approved for the treatment of some lymphoid malignancies as well as for autoimmune diseases including rheumatoid arthritis (RA), idiopathic thrombocytopenic purpura (ITP) and vasculitis. Generally, rituximab is well tolerated; nevertheless, some patients develop adverse effects including infusion reactions. Albeit rare, these reactions may in some cases be life‐threatening conditions. Rituximab cardiovascular side effects include more common effects such as hypertension, oedema and rare cases of arrhythmias and myocardial infarction. Case summary In this article, we report a case of a 58‐year‐old man with a history of overlap syndrome including RA and limited scleroderma who was treated with rituximab and developed a dramatic ST‐elevation myocardial infarction (STEMI) during the drug administration. What is new and conclusion This report underlines previous published reports emphasizing the awareness of such an association. This communication also warrants the importance of screening for ischaemic heart disease in selected cases of patients treated with rituximab.