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Adverse event due to a likely interaction between sodium aescinate and ginkgo biloba extract: a case report
Author(s) -
Ji H.,
Zhang G.,
Yue F.,
Zhou X.
Publication year - 2017
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/jcpt.12500
Subject(s) - ginkgo biloba , drug , discontinuation , medicine , pharmacology , drug interaction , adverse effect , nephrotoxicity , acute kidney injury , drug metabolism , anesthesia , kidney , surgery
Summary What is known and objective Drug‐induced nephrotoxicity is potentially lethal. When sodium aescinate is given to surgical inpatients to treat postoperative inflammation and oedema, adverse drug reactions and drug–drug interactions must be closely monitored. Case description We report a case of a 58‐year‐old man with phalangeal fractures who suffered from acute kidney injury that was most likely induced by the drug interaction between sodium aescinate and ginkgo biloba extract due to the protein‐binding and metabolic characteristics of these drugs. What is new and conclusion Close monitoring and the prompt discontinuation of drugs that have high protein‐binding capacity and hepatic metabolism are necessary to avoid drug–drug interactions in patients who are treated with sodium aescinate.