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Curing the historically incurable: treatment success with ledipasvir/sofosbuvir for chronic hepatitis C virus in a heavily treatment‐experienced individual
Author(s) -
Johnson S. W.,
Davis M. M.,
Stever L. M.,
Priest D. H.
Publication year - 2016
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/jcpt.12455
Subject(s) - sofosbuvir , ledipasvir , simeprevir , medicine , hepatitis c virus , virology , hepatitis c , chronic hepatitis , virus , ribavirin
Summary What is known and objective Significant progression in the treatment of chronic hepatitis C virus has been made with the introduction of direct‐acting antivirals ( DAA s). However, limited data are available for the retreatment of individuals who have failed multiple prior DAA s. Case description We report a single case of an individual who was unsuccessfully treated with five prior hepatitis C virus treatment regimens including simeprevir plus sofosbuvir who was successfully cured after treatment with ledipasvir/sofosbuvir. What is new and conclusion Ledipasvir/sofosbuvir may be an option for treating patients who have failed multiple prior DAA regimens; however, further research is warranted.