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Cross‐reactivity between voriconazole, fluconazole and itraconazole
Author(s) -
Benjamin Lash D.,
Jolliff J.,
Munoz A.,
Heidari A.
Publication year - 2016
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/jcpt.12417
Subject(s) - voriconazole , itraconazole , fluconazole , medicine , rash , dermatology , amphotericin b , maculopapular rash , antifungal
Summary What is known and objective Hypersensitivity to triazoles is a rare occurrence and cross‐reactivity between agents is unknown. We present a successful voriconazole challenge in a patient allergic to fluconazole and itraconazole. Case summary A 41‐year‐old immunocompetent male with coccidioidomycosis developed fever, eosinophilia and maculopapular rash from fluconazole. Switching to itraconazole resulted in worsening of the rash and skin sloughing over 25% of his body. He was given an oral‐graded challenge of voriconazole which he tolerated without incident. What is new and conclusion This is the first report of a lack of cross‐reactivity between itraconazole and voriconazole.