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The relative clinical efficacy of trametinib–dabrafenib and cobimetinib–vemurafenib in advanced melanoma: an indirect comparison
Author(s) -
GalvánBanqueri M.,
UbagoPérez R.,
MolinaLópez T.
Publication year - 2016
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/jcpt.12390
Subject(s) - trametinib , vemurafenib , dabrafenib , medicine , melanoma , randomized controlled trial , oncology , mek inhibitor , cancer , cancer research , metastatic melanoma , mapk/erk pathway , biology , kinase , microbiology and biotechnology
Summary What is known and objective Melanoma causes the majority of skin cancer‐related deaths. The outcome of melanoma depends on its stage at diagnosis. Currently, for patients with advanced melanoma, two MEK inhibitors (trametinib and cobimetinib) have been authorized by the European Medicines Agency. The main objective of this study was to compare the relative efficacy of trametinib–dabrafenib and cobimetinib–vemurafenib in patients with advanced melanoma through adjusted indirect treatment comparisons ( ITC s). Methods A search was made up to the 3rd of November 2015. Databases consulted were MEDLINE , the Cochrane Library and the Centre for Reviews and Dissemination. Randomized controlled trials ( RCT s) which compared the efficacy of trametinib–dabrafenib or cobimetinib–vemurafenib versus a common treatment comparator, in which outcomes of overall survival, progression‐free survival ( PFS ) and overall response rate ( ORR ) were considered. ITC s were carried out using the method proposed by Bucher et al . Results and discussion Two RCT s were included (one for each drugs combination). The results of the adjusted ITC s showed that there were no statistically significant differences between the two combinations in terms of PFS and ORR . What is new and conclusion The ITC s indicate no difference in efficacy between both treatments. However, there should be an independent, head‐to‐head trial of both combinations to confirm the results.