Premium
Peripheral arterial occlusive disease during ponatinib therapy after failure of imatinib: a case report
Author(s) -
Tournaire G.,
Despas F.,
Huguet F.,
Montastruc J. L.,
BondonGuitton E.
Publication year - 2016
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/jcpt.12383
Subject(s) - ponatinib , medicine , peripheral , imatinib , peripheral arterial occlusive disease , arterial disease , cardiology , vascular disease , surgery , nilotinib , myeloid leukemia
Summary What is known and objective Peripheral vascular adverse events have been reported with ponatinib treatment in chronic myeloid leukaemia ( CML ) after failure of dasatinib or nilotinib. We here report peripheral arterial occlusive disease ( PAOD ) in a patient who had previously received only imatinib as tyrosine kinase inhibitor. Case description The patient was a 70‐year‐old man with no history of cardiovascular disease. He developed arterial hypertension 5 months after the initiation of ponatinib and PAOD 41 months later. What is new and conclusion Peripheral arterial occlusive disease can occur several years after the initiation of ponatinib in patients who had previously received only imatinib. Long‐term surveillance is required for preventing the complications of ponatinib‐associated PAOD .