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Systematic review of red yeast rice compared with simvastatin in dyslipidaemia
Author(s) -
Ong Yi Chin,
Aziz Zoriah
Publication year - 2016
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/jcpt.12374
Subject(s) - simvastatin , red yeast rice , yeast , medicine , microbiology and biotechnology , traditional medicine , biology , biochemistry , alternative medicine , pathology
Summary What is known and objective Red yeast rice is believed to be a useful alternative in the management of dyslipidaemia. However, the comparative effectiveness of red yeast rice and simvastatin for the management of dyslipidaemia is unknown. This review assesses the efficacy and safety of red yeast rice versus simvastatin in dyslipidaemia. Methods Electronic databases were searched up to May 2015 without publication date and language restriction. The Cochrane Risk of Bias Assessment Tool was used to assess the quality of included trials. Changes in total cholesterol, low‐density lipoprotein cholesterol, high‐density lipoprotein cholesterol and triglycerides were examined. Results and discussion Ten randomized controlled trials involving 905 Chinese subjects with dyslipidaemia were systematically reviewed. Overall, red yeast rice and simvastatin did not show any statistically significant difference in any of the outcomes examined. What is new and conclusion A number of small trials show that red yeast rice and simvastatin produce similar lipid‐lowering effects. Larger trials with increased methodological rigour and trials with clinical outcomes are necessary for more robust inferences.