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A case of dysgraphia induced by sertraline and a review of official spontaneous adverse reaction databases
Author(s) -
Gentili M.,
Marinaccio P. M.,
Galimberti C.,
Carnovale C.,
Antoniazzi S.,
Pozzi M.,
Clementi E.,
Viganò C.,
Radice S.
Publication year - 2016
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/jcpt.12356
Subject(s) - dysgraphia , sertraline , adverse effect , medicine , database , psychology , psychiatry , pharmacology , computer science , philosophy , linguistics , anxiety , reading (process) , antidepressant , dyslexia
Summary What is known and objectives The occurrence of dysgraphia after sertraline intake has never been reported. The objective was to describe a case of this adverse drug reaction and present a review of similar cases held in international databases with a discussion of the possible pharmacological mechanisms. Case summary We observed a 60‐year‐old man who experienced resting tremors, dyskinesia and dysgraphia 2 months after a stepwise increase in sertraline dosing from 50 to 200 mg/day. What is new and conclusion Dysgraphia is a possible adverse drug reaction to sertraline, and we suggest that inhibition of extrapyramidal dopaminergic activity might be the pharmacological mechanism.