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Early optimization of antimicrobial therapy improves clinical outcomes of patients administered agents targeting methicillin‐resistant S taphylococcus aureus
Author(s) -
Niwa T.,
Watanabe T.,
Suzuki K.,
Hayashi H.,
Ohta H.,
Nakayama A.,
Tsuchiya M.,
Yasuda K.,
Murakami N.,
Itoh Y.
Publication year - 2016
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/jcpt.12341
Subject(s) - antimicrobial , medicine , staphylococcus aureus , methicillin resistant staphylococcus aureus , staphylococcal infections , anti infective agents , intensive care medicine , microbiology and biotechnology , bacteria , biology , genetics
Summary What is known and objective Antimicrobial stewardship is required to ensure the appropriate use of antimicrobials. However, no reports have been published on clinical outcomes of implementation of antimicrobial stewardship in patients receiving pathogen‐specific antibiotics. Method To evaluate the clinical outcomes of patients who received drugs, we conducted a single‐centre, retrospective study of the effects of an antimicrobial stewardship programme targeting methicillin‐resistant S taphylococcus aureus ( MRSA ). Results The time to administer effective antimicrobials was significantly (median number of days, 3 before vs. 0 after, P < 0·001) shortened, and the rate of de‐escalation was significantly elevated (47·1% vs. 96·2%, P < 0·001) after implementation of daily review. The 60‐day clinical failure associated with Gram‐positive bacterial infection was significantly reduced (33·3% vs. 17·6%, P = 0·007) after intervention. What is new and conclusions Daily review of administration of antimicrobials targeting MRSA was highly effective in improving clinical outcomes by optimizing early antimicrobial therapy.