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Initial experience of use of tolvaptan in critically ill patients with fluid overload
Author(s) -
RuizRamos J.,
Gordon M.,
Cortes M. A.,
Broch M. J.,
Ramirez P.
Publication year - 2015
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/jcpt.12255
Subject(s) - critically ill , medicine , tolvaptan , septic shock , fluid intake , diuresis , volume overload , intensive care medicine , shock (circulatory) , anesthesia , hyponatremia , renal function , sepsis , heart failure
Abstract What is known and objective Positive volume balance is related with high mortality in critically ill patients. We describe our experience in the use of tolvaptan in patients with fluid overload. Case summary Six patients in the recovery phase from septic shock were included. All patients achieved an increase in diuresis after the first day, with a median fluid balance variation of −2362 (−485 to −3447) mL. At the end of treatment, median fluid balance variation was −9080 (−26 784 to −4395) mL. What is new and Conclusion Tolvaptan could be an option in critically ill patients with fluid overload and resistant or not treatable with conventional diuretics.