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A clinical study of pingyangmycin sclerotherapy for venous malformation: an evaluation of 281 consecutive patients
Author(s) -
Bai N.,
Chen Y.Z.,
Fu Y.J.,
Wu P.,
Zhang W.N.
Publication year - 2014
Publication title -
journal of clinical pharmacy and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.622
H-Index - 73
eISSN - 1365-2710
pISSN - 0269-4727
DOI - 10.1111/jcpt.12183
Subject(s) - pingyangmycin , medicine , lidocaine , venous malformation , glans penis , bleomycin , anesthesia , sclerotherapy , dexamethasone , surgery , penis , chemotherapy , hemangioma
Summary What is known and objective In China, lidocaine together with 2 mg/mL of pingyangmycin ( PYM , also known as bleomycin A 5) is recommended for the treatment of venous malformations ( VM s). The purpose of this study was to investigate whether lidocaine has a synergistic effect with PYM in improving the therapeutic outcomes of patients with VM s. Additionally, this study aimed to evaluate the outcomes of sclerotherapy for VM s using an intralesional injection of a low concentration of PYM (0·5 mg/mL). Methods A total of 281 patients with VM s were treated with 0·5 or 2 mg/mL of PYM with or without lidocaine and dexamethasone ( DEX ). All of the patients received a direct intralesional injection at a rate of 1 mL/min, and the volume of the solution varied from 1·5 to 6·0 mL per injection. Results and discussion No significant differences were observed in the clinical outcomes between the PYM and PYM + lidocaine treatment groups ( P > 0·05). The clinical outcomes were similar between the groups that were treated with 0·5 and 2 mg/mL of PYM , but the swelling and pain in the patients who were treated with 0·5 mg/mL of PYM were less severe compared with the patients who were treated with 2 mg/mL of PYM . A total of 29 patients with VM lesions on the glans penis were treated with 0·5 mg/mL of PYM + 0·5% lidocaine. Of these patients, 26 were cured, whereas three experienced a marked improvement. What is new and conclusion Lidocaine does not have a synergistic effect with PYM in improving the therapeutic outcomes of patients with VM s. Sclerotherapy with a low concentration of PYM (0·5 mg/mL) combined with lidocaine and DEX is a safe and effective therapy for small superficial VM s of critical organs, such as the lips and the glans penis.