Premium
Annual Research Review: Anterior Modifiers in the Emergence of Neurodevelopmental Disorders (AMEND)—a systems neuroscience approach to common developmental disorders
Author(s) -
Johnson Mark H.,
Charman Tony,
Pickles Andrew,
Jones Emily J. H.
Publication year - 2021
Publication title -
journal of child psychology and psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.652
H-Index - 211
eISSN - 1469-7610
pISSN - 0021-9630
DOI - 10.1111/jcpp.13372
Subject(s) - cognitive reframing , developmental cognitive neuroscience , developmental psychopathology , psychopathology , psychology , neuroscience , developmental stage , neurodevelopmental disorder , developmental psychology , cognitive science , cognition , cognitive neuroscience , clinical psychology , psychotherapist , autism
We present the Anterior Modifiers in the Emergence of Neurodevelopmental Disorders (AMEND) framework, designed to reframe the field of prospective studies of neurodevelopmental disorders. In AMEND we propose conceptual, statistical and methodological approaches to separating markers of early‐stage perturbations from later developmental modifiers. We describe the evidence for, and features of, these interacting components before outlining analytical approaches to studying how different profiles of early perturbations and later modifiers interact to produce phenotypic outcomes. We suggest this approach could both advance our theoretical understanding and clinical approach to the emergence of developmental psychopathology in early childhood.