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Decreased anterior cingulate activation in a motor task in youths with bipolar disorder
Author(s) -
King Jace B.,
Anderson Jeffrey S.,
YurgelunTodd Deborah A.,
Subramaniam Punitha,
Ehrler Marie R.,
LopezLarson Melissa P.
Publication year - 2018
Publication title -
journal of child psychology and psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.652
H-Index - 211
eISSN - 1469-7610
pISSN - 0021-9630
DOI - 10.1111/jcpp.12875
Subject(s) - bipolar disorder , psychology , cbcl , mania , anterior cingulate cortex , attention deficit hyperactivity disorder , mood , child behavior checklist , functional magnetic resonance imaging , bipolar i disorder , supplementary motor area , audiology , neuroscience , psychiatry , cognition , medicine
Background Bipolar disorder (BP) is characterized by abnormal shifts in mood between episodes of mania and severe depression, both of which have been linked with psychomotor disturbances. This study compares brain activation patterns in motor networks between euthymic youths with BP and healthy controls (HC) during the completion of a simple motor task. Methods Thirty‐five youths with BP and 35 HC (aged 10–19) completed a self‐paced sequential bilateral finger‐tapping task, consisting of a 4‐minute scan block with alternating 20‐second periods of either the tapping task (six blocks) or rest (six blocks), while undergoing functional magnetic resonance imaging. Clinical and behavioral symptoms were assessed using the Child Behavior Checklist (CBCL). A between‐group whole‐brain analysis compared activation pattern differences while controlling for effects of age and sex. Clusters meeting whole‐brain false discovery rate (FDR) correction ( qFDR < .05) were considered statistically significant. Post hoc analyses evaluating comorbid attention‐deficit/hyperactivity disorder (ADHD) in the BP group were also conducted. Results Significantly decreased activation was found in the anterior cingulate cortex (ACC) in youths with BP compared to HC. Furthermore, ACC activation was negatively correlated with CBCL mood dysregulation profile scores in the BP group. No significant differences in functional activation patterns were found between youths with BP and comorbid ADHD and those with only BP. Conclusions These findings suggest a potential common mechanism of impaired ACC modulation between emotion dysregulation and motor processing in youths with BP.