z-logo
Premium
Structural and functional connectivity in children and adolescents with and without attention deficit/hyperactivity disorder
Author(s) -
Bos Dienke J.,
Oranje Bob,
Achterberg Michelle,
Vlaskamp Chantal,
Ambrosino Sara,
Reus Marcel A.,
Heuvel Martijn P.,
Rombouts Serge A.R.B.,
Durston Sarah
Publication year - 2017
Publication title -
journal of child psychology and psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.652
H-Index - 211
eISSN - 1469-7610
pISSN - 0021-9630
DOI - 10.1111/jcpp.12712
Subject(s) - resting state fmri , default mode network , psychology , functional connectivity , attention deficit hyperactivity disorder , prefrontal cortex , superior frontal gyrus , functional magnetic resonance imaging , neuroscience , white matter , inferior frontal gyrus , frontal lobe , brain mapping , audiology , cognition , psychiatry , magnetic resonance imaging , medicine , radiology
Background Attention deficit/hyperactivity disorder ( ADHD ) has frequently been associated with changes in resting‐state functional connectivity, and decreased white matter ( WM ) integrity. In the current study, we investigated functional connectivity within Default Mode and frontal control resting‐state networks ( RSN s) in children with and without ADHD . We hypothesized the RSN s of interest would show a pattern of impaired functional integration and segregation and corresponding changes in WM structure. Methods Resting‐state f MRI and diffusion‐weighted imaging data were acquired from 35 participants with ADHD and 36 matched typically developing peers, aged 6 through 18 years. Functional connectivity was assessed using independent component analysis. Network topology and WM connectivity were further investigated using graph theoretical measures and tract‐based spatial statistics ( TBSS ). Results Resting‐state f MRI analyses showed increased functional connectivity in right inferior frontal gyrus ( IFG ), and bilateral medial prefrontal cortex (m PFC ) within the Default Mode and frontal control networks. Furthermore, a more diffuse spatial pattern of functional connectivity was found in children with ADHD . We found no group differences in structural connectivity as assessed with TBSS or graph theoretical measures. Conclusions Resting‐state networks show a more diffuse pattern of connectivity in children with ADHD . The increases in functional connectivity in right IFG and bilateral m PFC in children with ADHD may reflect reduced or delayed functional segregation of prefrontal brain regions. As these functional changes were not accompanied by changes in WM , they may precede the development of the frequently reported changes in WM structure.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here