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Common infections with polyomaviruses and herpesviruses and neuropsychological development at 4 years of age, the Rhea birth cohort in Crete, Greece
Author(s) -
Karachaliou Marianna,
Chatzi Leda,
Roumeliotaki Theano,
Kampouri Mariza,
Kyriklaki Andriani,
Koutra Katerina,
Chalkiadaki Georgia,
Michel Angelika,
Stiakaki Eftichia,
Kogevinas Manolis,
Pawlita Michael,
Waterboer Tim,
Sanjose Silvia
Publication year - 2016
Publication title -
journal of child psychology and psychiatry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.652
H-Index - 211
eISSN - 1469-7610
pISSN - 0021-9630
DOI - 10.1111/jcpp.12582
Subject(s) - seroprevalence , serology , cohort , serostatus , medicine , polyomavirus infections , cytomegalovirus , pediatrics , herpes simplex virus , immunology , herpesviridae , virology , virus , viral disease , antibody , bk virus , viral load , transplantation , kidney transplantation
Background Viral infections of the central nervous system may have detrimental effects for the developing brain, but the effects of less virulent common infections are unclear. We aim to investigate the impact of common viral infections of early childhood on neuropsychological performance of children at age four. Methods We used cross‐sectional data on 674 children participating at the 4 years of age follow‐up of the Rhea birth cohort in Crete, Greece. Blood levels of IgG antibodies to 10 polyomaviruses ( BKP yV, JCP yV, KIP yV, WUP yV, HP yV6, HP yV7, TSP yV, MCP yV, HP yV9, and HP yV10) and four herpesviruses [Epstein–Barr virus ( EBV ), cytomegalovirus ( CMV ), herpes simplex virus‐1 ( HSV ‐1), and herpes simplex virus‐2 ( HSV ‐2)] were measured using multiplex serology. Child's neuropsychological development at age four was assessed using the McCarthy Scales of Children's Abilities, the Attention‐Deficit Hyperactivity Disorder Test ( ADHDT ), and the Strengths and Difficulties Questionnaire ( SDQ ). Multiple linear regression models were used to explore the associations. Results Seroprevalence to polyomaviruses ranged from 21% for HP yV9 to 82% for HP yV10. Seroprevalence for EBV was 53%, for CMV 26%, for HSV ‐1 3.6%, and for HSV ‐2 1.5%. Children seropositive to ≥8 polyomaviruses had lower score in ADHDT inattention subscale [β = −1.28 (95% CI : −2.56, −0.001)] and lower score in SDQ hyperactivity–inattention subscale [β = −.99 (95% CI : −1.60, −0.37)] versus children seropositive to ≤3 polyomaviruses. Seropositivity to BKP yV, a potential neurotropic virus, was associated with higher score in ADHDT inattention subscale [β = .87 (95% CI : 0.03, 1.71)]. Conclusions These findings suggest that acquisition of polyomaviruses during development may influence behavioral outcomes in early childhood.