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Micro‐angiogenic patterns around orthodontic implants migrating in bone: A micro‐CT study in the rat tail model
Author(s) -
Hüfner Mira,
Rauch Nicole,
SchwarzHerzke Beryl,
Knorr Ivonne Jeanette,
Sager Martin,
Drescher Dieter,
Becker Kathrin
Publication year - 2022
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/jcpe.13577
Subject(s) - implant , x ray microtomography , perfusion , blood vessel , anatomy , biomedical engineering , materials science , medicine , surgery , radiology
Abstract Aim Recent studies revealed that implants can migrate in bone when subjected to continuous loading. Since this process is suspected to be accompanied by bone remodelling, which requires blood vessel formation, the present work aimed at assessing the micro‐angiogenic patterns around migrating implants. Materials and methods In 16 rats, two customized implants were placed in a single tail vertebra and connected with contraction springs (forces: 0 N, 0.5 N, 1.0 N, 1.5 N). After 2 or 8 weeks of loading, the animals were scanned by micro‐CT before and after vasculature perfusion with a silicone rubber. Vessels were segmented by subtraction of the two micro‐CT scans. Vessel thickness (V.Th), vessel volume per total volume (VV/TV), and vascular spacing (V.Sp) were assessed in a peri‐implant volume of interest (VOI) around each implant. Results At 2 weeks of loading, force magnitude was significantly associated with VV/TV and V.Th values ( χ 2 = 10.942, p < .001 and χ 2 = 6.028, p = .010, respectively). No significant differences were observed after 8 weeks of loading. Conclusions Within the limitations of an animal study, peri‐implant vessel thickness and density were associated with force magnitude in the early loading phase, whereas effects diminished after 8 weeks of loading.