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Prolonged multimodal fasting modulates periodontal inflammation in female patients with metabolic syndrome: A prospective cohort study
Author(s) -
Pappe Christina Laetitia,
Steckhan Nico,
Hoedke Daniela,
Jepsen Søren,
Rauch Geralinde,
Keller Theresa,
Michalsen Andreas,
Dommisch Henrik
Publication year - 2021
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/jcpe.13419
Subject(s) - medicine , metabolic syndrome , waist , gastroenterology , bleeding on probing , prospective cohort study , inflammation , body mass index , gingival inflammation , c reactive protein , periodontitis , obesity , periodontal disease
Aim To determine the potential anti‐inflammatory effect of a multimodal periodic fasting programme on surrogate parameters of periodontal inflammation in hospitalized patients diagnosed for metabolic syndrome (MetS). Material and methods A total of 47 patients were recruited and hospitalized in an integrative ward for an intensified two‐week multimodal fasting, diet and lifestyle programme. Patients were periodontally examined at baseline (t1), after the 2‐week fasting protocol (t2) and, subsequently, 4 months after fasting (t3). The following parameters were determined: periodontal screening index (PSI), bleeding on probing (BOP), gingival crevicular fluid volume (GCF), plaque index (PI), C‐reactive protein (CRP), blood pressure (BP), waist circumference (WC), fasting glucose (FGLU), triglycerides (TRG), high‐density lipoprotein (HDL) and HbA1c. Results A total of 28 female and 8 male patients fulfilled the defined criteria for MetS and were analysed separately by gender. At t2, BOP and GCF were reduced when compared to t1 (median: t2 = 39; t1 = 33.1%; p < .001 and t2 = 73.9; t1 = 59.3 Periotron units p = .02, respectively). BOP reduction correlated to FGLU ( R = .37, p = .049) and weight reduction ( R = .4, p = .04). Conclusion This study showed for the first time that clinically supervised periodic fasting in female patients with MetS may facilitate the reduction of periodontal inflammation.