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The systemic inflammatory response following hand instrumentation versus ultrasonic instrumentation—A randomized controlled trial
Author(s) -
Johnston William,
Paterson Michael,
Piela Krystyna,
Davison Emily,
Simpson Annabel,
Goulding Marilyn,
Ramage Gordon,
Sherriff Andrea,
Culshaw Shauna
Publication year - 2020
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/jcpe.13342
Subject(s) - medicine , debridement (dental) , randomized controlled trial , ultrasonic sensor , periodontitis , c reactive protein , body mass index , surgery , gastroenterology , dentistry , inflammation , radiology
Objective This study sought to investigate whether the immediate systemic inflammatory response following full‐mouth debridement differs following use of hand compared with ultrasonic instruments. Methods Thirty‐nine periodontitis patients were randomized to treatment with full‐mouth debridement using either hand or ultrasonic instrumentation completed within 24 hr. Serum and periodontal clinical parameters were collected at baseline, day 1, day 7 and day 90 post‐treatment. Differences in systemic inflammatory markers were assessed using general linear models at each timepoint, corrected for age, gender, smoking status, body mass index and baseline levels of each marker. Results Across all patients, serum C‐reactive protein increased at day 1, with no differences between hand and ultrasonic groups ( p (adjusted) = .22). There was no difference between groups in interleukin‐6 ( p (adjusted) = .29) or tumour necrosis factor α ( p (adjusted) = .53) at day 1. Inflammatory markers returned to baseline levels by day 7. Treatment resulted in equal and marked improvements in clinical parameters in both groups; however, total treatment time was on average shorter for ultrasonic instruments ( p (adjusted) = .002). Conclusions Ultrasonic instrumentation resulted in shorter treatment time with comparable clinical outcomes. Levels of serum C‐reactive protein at day 1 were similar following debridement with hand or ultrasonic instruments.