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Effects of adjunctive probiotic L. reuteri lozenges on S/RSD outcomes at molar sites with deep pockets
Author(s) -
Pelekos Georgios,
Acharya Aneesha,
Eiji Nemoto,
Hong Guang,
Leung Wai Keung,
McGrath Colman
Publication year - 2020
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/jcpe.13329
Subject(s) - lactobacillus reuteri , medicine , placebo , probiotic , molar , lozenge , dentistry , randomized controlled trial , biology , history , genetics , alternative medicine , archaeology , pathology , bacteria
Aim To evaluate effects of probiotic Lactobacillus reuteri ( L. reuteri ) lozenges as an S/RSD adjunct on site‐level changes at molars with deep pockets. Materials and methods 447 molar sites with pockets ≥ 5 mm from a previous randomized clinical trial of adjunctive L. reuteri lozenges for 28 days were analyzed. Multilevel mixed‐effect models (MLM) were constructed to analyze site‐level outcomes “change in CAL” and “pocket closure” (residual PPD < 5 mm) in placebo and probiotic groups at 90 and 180 days. Possible patient‐, tooth‐, and site‐level predictors were analyzed as fixed‐effects. Results Estimated change in CAL in probiotic (90 day: 0.87 mm, 180 day: 0.68 mm) was greater than placebo treated molar sites (90 day: 0.73 mm, 180 day: 0.66 mm) and the relative risk (RR) of pocket closure in the probiotic group (90 day: 1.7, 180 day: 1.6) was higher as compared to placebo. Furcation involvement and BOP at site predicted significantly worse treatment outcomes. Conclusion As compared to S/RSD with placebo, a 28‐day course of adjunctive probiotic L. reuteri lozenges improved CAL change at molar sites with ≥ 5 mm deep pockets and conferred a higher probability of shallow residual pocket depth. Presence of furcation‐involvement and bleeding on probing worsened treatment outcomes.