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A randomized controlled trial of the effects of non‐surgical periodontal therapy on cardiac function assessed by echocardiography in type 2 diabetic patients
Author(s) -
Wang Yi,
Liu Hin Nam,
Zhen Zhe,
Pelekos George,
Wu Mei Zhen,
Chen Yan,
Tonetti Maurizio,
Tse Hung Fat,
Yiu Kai Hang,
Jin Lijian
Publication year - 2020
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/jcpe.13291
Subject(s) - medicine , periodontitis , cardiology , oral hygiene , natriuretic peptide , cardiac function curve , ventricle , type 2 diabetes mellitus , diabetes mellitus , gastroenterology , diastole , body mass index , dentistry , endocrinology , heart failure , blood pressure
Background Periodontitis significantly increases the risk of diabetic complications. This clinical trial investigated the effects of periodontal therapy on cardiac function in patients with type 2 diabetes mellitus (T2DM) and periodontitis. Materials and methods Fifty‐eight subjects with T2DM and periodontitis were randomly allocated to Treatment Group ( n = 29) receiving non‐surgical periodontal therapy, and Control Group ( n = 29) having only oral hygiene instructions with delayed periodontal treatment until completion of this 6‐month study. The left ventricle (LV) diastolic function was assessed by echocardiography with the tissue Doppler imaging index (E/e' ratio); and LV hypertrophy was evaluated by LV mass index (LVMI). Blood samples were collected for biochemical analysis. Results The intention‐to‐treat analysis showed that periodontal treatment significantly reduced the E/e' ratio by 1.66 (95% CI: −2.64 to −0.68, p < .01), along with marked improvement of periodontal conditions ( p < .05). LVMI was not altered at the 6‐month follow‐up. The serum levels of N‐terminal pro‐B type natriuretic peptide (NT‐proBNP) as a cardiac stress biomarker, C‐reactive protein and interleukin‐6 decreased numerically without reaching statistical significance. Conclusion The present study provides the first evidence that non‐surgical periodontal therapy may improve cardiac diastolic function in type 2 diabetic patients with periodontitis.