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Periodontitis and systemic markers of neurodegeneration: A case–control study
Author(s) -
Leira Yago,
Carballo Álvaro,
Orlandi Marco,
Aldrey José Manuel,
PíasPeleteiro Juan Manuel,
Moreno Federico,
VázquezVázquez Laura,
Campos Francisco,
D’Aiuto Francesco,
Castillo José,
Sobrino Tomás,
Blanco Juan
Publication year - 2020
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/jcpe.13267
Subject(s) - periodontitis , medicine , systemic inflammation , gastroenterology , inflammation , c reactive protein , chronic periodontitis , acute phase protein
Abstract Aim To investigate whether periodontitis is associated with amyloid beta (Aβ) peptides and whether systemic inflammation could act as a potential mediator of this link. Materials and Methods A case–control study was designed including 75 patients with periodontitis (cases) and 75 age‐balanced and gender‐matched participants without periodontitis (controls). Full‐mouth periodontal evaluation was performed in all participants. Demographic, clinical and behaviour data were also recorded. Fasting blood samples were collected, and serum levels of interleukin 6 (IL‐6), high‐sensitivity C‐reactive protein (hs‐CRP), Aβ 1‐40 and Aβ 1‐42 were determined. Results Cases showed higher levels of IL‐6 (8.7 ± 3.2 vs. 4.8 ± 0.5 pg/ml), hs‐CRP (3.3 ± 1.2 vs. 0.9 ± 0.7 mg/L), Aβ 1‐40 (37.3 ± 6.0 vs. 30.3 ± 1.8 pg/ml) and Aβ 1‐42 (54.5 ± 10.6 vs. 36.5 ± 10.0 pg/ml) when compared to controls (all p < .001). Diagnosis of periodontitis was statistically significantly associated with circulating Aβ 1‐40 ( βcoefficient adjusted = 6.9, 95% CI: 5.4–8.3; p < .001) and Aβ 1‐42 ( βcoefficient adjusted = 17.8, 95% CI: 14.4–21.3; p < .001). Mediation analysis confirmed hs‐CRP and IL‐6 as mediators of this association. Conclusions Periodontitis is associated with increased peripheral levels of Aβ. This finding could be explained by enhanced systemic inflammation that can be seen in patients with periodontitis.