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Periodontal pathogens and their role in cardiovascular outcome
Author(s) -
Schulz Susanne,
Schlitt Axel,
Hofmann Britt,
Schaller HansGünter,
Reichert Stefan
Publication year - 2020
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/jcpe.13224
Subject(s) - eikenella corrodens , tannerella forsythia , medicine , prevotella intermedia , fusobacterium nucleatum , capnocytophaga , periodontitis , gastroenterology , treponema denticola , risk factor , porphyromonas gingivalis , biology , pathology , honeysuckle , genetics , alternative medicine , traditional chinese medicine , bacteria
Aim Periodontitis has been identified as a moderate but independent risk factor for cardiovascular (CV) disease and progression. The objective of this study (ClinicalTrials.gov Identifier: NCT01045070) was to assess subgingival colonization with selected periodontal pathogens on the occurrence of further adverse CV events in a cohort of CV patients. Methods The prevalence of severe periodontitis including the detection of 11 periodontal pathogens ( Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, Tannerella forsythia, Treponema denticola, P. intermdia, Peptostreptococcus micros, Fusobacterium nucleatum, Campylobacter rectus, Eubacterium nodatum, Eikenella corrodens, Capnocytophaga sputigena, Capnocytophaga gingivalis, Capnocytophaga ochracea ; HAIN‐Diagnostica ® ) was analysed in 1,002 CV patients The prognostic impact of periodontal pathogens for combined CV endpoint (stroke/TIA, myocardial infarction, CV death, death from stroke) was evaluated after a 3‐year follow‐up period. Hazard ratios (HRs) were adjusted for established CV risk factors applying Cox regression. Results In the Kaplan–Meier analysis (log‐rank test: p < .001) and Cox regression (HR: 0.545, 95%‐CI: 0.387–0.773; p = .001), the decreased occurrence of E. corrodens was shown to be an independent predictor for adverse CV events after 3 years of follow‐up. Conclusions The detection of E. corrodens was associated with a reduced risk of adverse CV events in patients with CV disease. The pathophysiological background underlying this association should be investigated in further studies.