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Association between periodontitis and the risk of inadequate disease control in patients with rheumatoid arthritis under biological treatment
Author(s) -
Chen HsinHua,
Chen DerYuan,
Huang LiangGie,
Chen YiMing,
Hsieh ChiaWei,
Hung WeiTing,
Tang KuoTung,
Chen Gin
Publication year - 2020
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/jcpe.13213
Subject(s) - medicine , rheumatoid arthritis , periodontitis , logistic regression , disease , prospective cohort study , arthritis , diabetes mellitus , gastroenterology , endocrinology
Aim To assess the association between periodontitis (PD) and inadequate disease control (IDC) in patients with rheumatoid arthritis (RA) receiving biological therapy. Materials and methods In total, 111 RA patients receiving biological therapy for at least 3 months were assessed for periodontal disease at baseline. RA disease activity was assessed at baseline and at 3 months of follow‐up. A multivariable logistic regression analysis was used to estimate the association between PD and IDC, adjusting for age, sex, smoking, diabetes, and baseline RA disease activity. An additional exploratory model further controlled for disease characteristics and other medications. Results Among 111 patients, 84 (75.7%) had PD, of whom 37 (44.0%) received periodontal treatment. Thirty‐four (40.5%) of PD patients had IDC; 12 (32.4%) of treated PD patients and 22 (46.8%) of untreated patients had IDC, respectively. The ORs (95% CIs) for IDC were 1.45 (0.50–4.23) in PD patients and 1.84 (0.59–5.76) in untreated PD patients. In the exploratory model, the ORs (95% CIs) for IDC were 5.00 (1.19–21.03) in PD patients and 6.26 (1.34–29.34) in untreated PD patients. Conclusion This single‐centre, prospective study failed to demonstrate a consistently positive correlation between PD and IDC in RA patients receiving biological treatment.