Premium
A double‐blind, paralleled‐arm, placebo‐controlled and randomized clinical trial of the effectiveness of probiotics as an adjunct in periodontal care
Author(s) -
Pelekos George,
Ho Sze Nga,
Acharya Aneesha,
Leung Wai Keung,
McGrath Colman
Publication year - 2019
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/jcpe.13191
Subject(s) - medicine , placebo , periodontitis , lactobacillus reuteri , clinical trial , randomized controlled trial , probiotic , clinical endpoint , dentistry , gastroenterology , pathology , alternative medicine , biology , bacteria , genetics
Aim This study aimed to evaluate the clinical effectiveness of the probiotic Lactobacillus reuteri as an adjunct to non‐surgical periodontal therapy (NSPT). Materials and Methods A double‐blind, paralleled‐arm, placebo‐controlled and randomized clinical trial was conducted. Probiotics L. reuteri or placebo lozenges were randomly prescribed for use twice‐daily for 28 days. Primary outcomes were clinical attachment levels (CAL) and probing pocket depths (PPD). All participants underwent NSPT, and follow‐up clinical assessments were performed at day 90 and day 180. Results The trial response rate was 69.5% (41 out of 59). Among the test and control groups, there were significant intra‐group differences in primary outcomes: CAL (both, p < .001) and PPD (both, p < .001); and in secondary outcomes: percentage of sites with ‘bleeding on probing’ (both, p < .001) and visible plaque (both, p < .001). There were no statistically significant inter‐group differences in any outcomes at any time points (all, p > .05) nor in the changes in outcomes (∆) with time (all, p > .05). There was a trend of a greater magnitude of statistical change occurring among the test group compared to the control group. Conclusion The adjunctive use of probiotics with NSPT did not show any additional clinical effectiveness when compared to NSPT alone in the management of periodontitis (ChiCTR‐IOR‐17010526).