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Antineoplastic agents exacerbate periodontal inflammation and aggravate experimental periodontitis
Author(s) -
Gusman David Jonathan Rodrigues,
Ervolino Edilson,
Theodoro Letícia Helena,
Garcia Valdir Gouveia,
Nagata Maria José Hitomi,
Alves Breno Edson Sendão,
Araujo Nathalia Januario,
Matheus Henrique Rinaldi,
Almeida Juliano Milanezi
Publication year - 2019
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/jcpe.13101
Subject(s) - periodontitis , inflammation , medicine , tumor necrosis factor alpha , immunohistochemistry , interleukin , cisplatin , saline , pathology , gastroenterology , chemotherapy , cytokine
Abstract Aim This study evaluated the effects of 5‐fluorouracil (5‐FU) and cisplatin (CIS) in healthy periodontal tissues and in the early stages of experimental periodontitis (EP) in rats. Methods One hundred and eighty male rats were divided into three groups, which were submitted to the following systemic treatments: physiological saline solution (PSS); CIS and 5FU. Each group was subdivided into two subgroups: without (NEP) and with (EP) induction of EP. Animals were euthanized at 3, 5 and 7 days post‐treatment. Histological, histometric (percentage of bone in the furcation [PBF]) and immunohistochemical (for tumour necrosis factor‐α, interleukin‐1β and receptor activator of nuclear factor‐κB ligand) analyses were performed. Data were statistically analysed. Results CIS‐NEP and 5FU‐NEP showed more inflammation than PSS‐NEP at 3, 5 and 7 days. CIS‐EP and 5FU‐EP showed more inflammation and lower PBF than PSS‐EP at all periods of evaluation. 5FU‐EP showed lower PBF than CIS‐EP at 5 and 7 days. Conclusion 5‐FU and CIS exacerbated periodontal inflammation and aggravated the progression of EP in its early stages.