Premium
Chronic periodontitis and reduced respiratory function
Author(s) -
Winning Lewis,
Patterson Christopher C.,
Cullen Kathy M.,
Kee Frank,
Linden Gerard J.
Publication year - 2019
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/jcpe.13076
Subject(s) - medicine , confounding , periodontitis , spirometry , anthropometry , tooth loss , clinical attachment loss , chronic periodontitis , logistic regression , physical therapy , dentistry , asthma , oral health
Objective To investigate whether there was an association between chronic periodontitis (CP) and reduced respiratory function. Methods A group of dentate 58‐ to 72‐year‐old men in Northern Ireland had a comprehensive periodontal examination. Parallel to the periodontal examination, participants completed questionnaires gathering information on their medical history, social circumstances, demographic background and tobacco use. A physical examination assessed anthropometric measures. Fasting blood samples were obtained and analysed for high‐sensitivity C‐reactive protein (hs‐ CRP ). Spirometry measures were performed using a wedge bellows spirometer (Vitalograph S Model). The primary outcome variable of interest was the percentage predicted forced expiratory volume in one‐second (% predicted FEV 1 ). Analysis included multiple linear regression with adjustment for various confounders and a regression‐based mediation analysis. Results A total of 1,380 men were included in the analysis. The mean age was 63.7 years ( SD 3.0). Multiple linear regression analysis showed that a doubling in mean clinical attachment loss ( CAL ) equated to a −3.33% (95% CI : −4.80, −1.86), p < 0.001 change in % predicted FEV 1 after adjustment for all other potential confounding variables. Systemic inflammation, as measured by hs‐ CRP , only accounted for a minor mediating pathway effect (9%). Conclusions In this homogenous group of dentate men, CP was significantly associated with a reduced respiratory function.