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The critical interplay between bone resorbing and bone forming cells
Author(s) -
Lerner Ulf H.,
Kindstedt Elin,
Lundberg Pernilla
Publication year - 2019
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/jcpe.13051
Subject(s) - sclerostin , bone resorption , bone remodeling , microbiology and biotechnology , bone remodeling period , bone cell , bone formation , chemistry , osteoclast , resorption , osteoimmunology , osteoblast , medicine , endocrinology , wnt signaling pathway , biology , signal transduction , in vitro , receptor , rankl , biochemistry , activator (genetics)
Abstract Aim In this article, the interplay between bone resorbing and bone forming cells is reviewed. Method This review examines the comprehensive literature on the interaction between bone resorption and bone formation. Results Coupling between bone resorption and bone formation refers to the process within basic multicellular units, in which osteoclastic bone resorption is met by the differentiation of osteoblasts and their bone forming activity. There are many possible signalling molecules that contribute to coupling at the asynchronously working remodelling sites throughout our skeleton. These include growth factors released from the bone matrix during bone resorption, soluble and membrane products of the osteoclasts and their precursors and signals from osteocytes. Conclusions In this review, we describe the potential roles of a number of these factors, whose interactions are essential for a tight control of coupling within individual remodelling units, in order to control skeletal mass. Both pre‐clinical evidence and clinical evidence pinpoint that molecules in the WNT signalling pathway could be promising bone augmentation therapeutic targets. Regarding oral implications, there is support, from preclinical studies in rats, that anti‐sclerostin antibodies can restore alveolar bone mass.