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The antidepressant drug, sertraline, hinders bone healing and osseointegration in rats’ tibiae
Author(s) -
Abu Nada Lina,
Al Subaie Ahmed,
Mansour Alaa,
Wu Xixi,
Abdallah MohamedNur,
AlWaeli Haider,
Ersheidat Ala’,
Stone Laura S.,
Murshed Monzur,
Tamimi Faleh
Publication year - 2018
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/jcpe.13015
Subject(s) - osseointegration , sertraline , bone healing , tibia , medicine , dentistry , implant , antidepressant , surgery , hippocampus
Aim Selective serotonin reuptake inhibitors (SSRIs) are one of the most common antidepressant drugs. SSRI use is associated with increased risk of bone fracture and titanium implant failure. The aim of this in vivo study was to investigate the effect of SSRIs on osseointegration and bone healing. Materials and Methods On a total of 24 Sprague‐Dawley rats, a custom‐made titanium implant was placed in the left tibia, while a unicortical defect was created in the right tibia. Rats were assigned randomly into two groups and received a daily dose of either sertraline (5 mg/kg) or saline. After two weeks, they were euthanized and bone healing and osseointegration were assessed by micro‐CT and histology. Results Bone formation in bone defects was significantly lower ( p < 0.05) in sertraline‐treated rats (BV/TV = 20.67 ± 11.98%) compared to the controls (BV/TV = 37.87 ± 9.56%). Furthermore, the percentage of osseointegration was significantly lower ( p < 0.05) in sertraline‐treated rats (34.40 ± 7.17%) compared to the controls (54.37 ± 8.58%). Conclusion Sertraline hinders bone healing and implant osseointegration.