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Effects of the prebiotic mannan oligosaccharide on the experimental periodontitis in rats
Author(s) -
Levi Yara L. A. S.,
Novais Gabriela S.,
Dias Raisa B.,
Andraus Rodrigo A. C.,
Messora Michel R.,
Neto Hermann B.,
Ervolino Edilson,
Santii Carolina S.,
Maia Luciana P.
Publication year - 2018
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/jcpe.12987
Subject(s) - prebiotic , periodontitis , dental alveolus , molar , chemistry , medicine , dentistry , biochemistry
Aim To evaluate the effect of the prebiotic ( PREB ) mannan oligosaccharide ( MOS ) on the progression of the experimental periodontitis ( EP ) and intestinal morphology in rats. Materials and Methods Forty rats were randomly allocated into groups ( n = 10): C (control), PREB , EP and EP ‐ PREB . Groups PREB and EP ‐ PREB received MOS incorporated into the feed daily. After 30 days, groups EP and EP ‐ PREB received a cotton ligature around their mandibular first molars, kept for 14 days. Morphometrical, histomorphometrical, microcomputed tomography, gene expression analyses and immunohistochemistry were performed. Data were statistically analysed ( p < 0.05). Results Group EP ‐ PREB showed less interproximal bone loss, area without bone in the furcation and bone porosity, and greater bone mineral density than group EP ( p < 0.05). It was also observed a significant decrease in IL ‐10 and IFN ‐γ gene expression, besides a decrease in TNF ‐α and IL ‐1β and an increase in TGF ‐β immunolabeling score for group EP ‐ PREB . Group EP ‐ PREB also presented villous height and crept depth values similar to group C, while group EP presented reduced values ( p < 0.05). Conclusion It can be concluded that the oral administration of MOS promotes a protective effect against alveolar bone loss caused by EP in rats, modifying histologic and immune‐inflammatory parameters, in addition to protecting the intestine.