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Saliva and serum biomarkers in periodontitis and coronary artery disease
Author(s) -
Lahdentausta Laura S. J.,
Paju Susanna,
Mäntylä Päivi,
Buhlin Kåre,
Tervahartiala Taina,
Pietiäinen Milla,
Alfthan Henrik,
Nieminen Markku S.,
Sinisalo Juha,
Sorsa Timo,
Pussinen Pirkko J.
Publication year - 2018
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/jcpe.12976
Subject(s) - medicine , saliva , periodontitis , acute coronary syndrome , myeloperoxidase , gastroenterology , coronary artery disease , periodontium , biomarker , chronic periodontitis , population , dentistry , inflammation , myocardial infarction , biochemistry , environmental health , chemistry
Aim Matrix metalloproteinase ( MMP )‐8, MMP ‐9, tissue inhibitor of matrix metalloproteinase ( TIMP )‐1 and myeloperoxidase ( MPO ) participate in extracellular matrix breakdown both in periodontium and atherosclerotic plaques. We investigated the diagnostic value of serum and saliva biomarkers in periodontitis and acute coronary syndrome ( ACS ). Materials and methods The population was PAROGENE ( n = 481), a random cohort of patients with an indication for coronary angiography. All patients underwent a clinical and radiographic oral examination. Groups consisting of periodontitis versus non‐periodontitis, and ACS versus non‐ ACS patients were compared. Results Saliva MMP ‐8, MMP ‐9 and MPO provided significant area‐under‐curve ( AUC ) values for periodontitis, 0.69 (<0.001), 0.66 (<0.001) and 0.68 (<0.001), respectively. Serum MMP ‐8, MMP ‐9 and MPO levels distinguished ACS from non‐ ACS patients with AUC s of 0.73 (<0.001), 0.58 (0.03) and 0.68 (<0.001), respectively. Periodontitis confounded the use of serum MMP ‐9 in diagnostics of ACS . Cardiac status complicated the use of saliva TIMP ‐1 in periodontal diagnostics. Saliva biomarkers could not be used in ACS diagnosis, and serum biomarkers were not useful in diagnosis of periodontitis. Conclusions MMP ‐8, MMP ‐9, TIMP ‐1and MPO are valuable biomarkers for both ACS and periodontitis, but the selection of sample material is crucial; serum is suitable for ACS and saliva for periodontal diagnostic aid.