Premium
Relationship between vitamin D receptor gene polymorphism and susceptibility to chronic kidney disease and periodontal disease in community‐dwelling elderly
Author(s) -
Yoshihara Akihiro,
Kaneko Noboru,
Iwasaki Masanori,
Nohno Kaname,
Miyazaki Hideo
Publication year - 2018
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/jcpe.12896
Subject(s) - calcitriol receptor , medicine , renal function , kidney disease , genotype , odds ratio , quartile , genotyping , vitamin d and neurology , logistic regression , gastroenterology , biology , gene , confidence interval , genetics
Objectives The aim of this study was to investigate the possible correlation between vitamin D receptor ( VDR ) gene polymorphism and susceptibility to chronic kidney disease ( CKD ) and periodontal disease. Material and Methods This study analysed 345 participants, who were all 79 years of age. Kidney function levels were determined based on the estimated glomerular filtration rate ( eGFR ; non‐reduced function: ≥60 and reduced function: <60 ml min −1 1.73 m −2 ). VDR Taq I genotyping was also studied. We calculated the periodontal inflamed surface area ( PISA ). After classifying participants into quartile groups according to eGFR or PISA values, the subjects were then split into two groups (highest quartile versus the other three groups combined). Multiple logistic regression analysis was performed to evaluate the odds ratios between the eGFR and VDR Taq I genotype with the different PISA groups. The eGFR was set as the dependent variable while the VDR Taq I genotype, HbA1C, gender, smoking habits and body mass index were defined as independent variables. Results A significant association was observed between the VDR Taq I genotype and eGFR in the PISA high group (odds ratio = 3.97, p = .027). Conclusion Study results suggest that VDR Taq I genotype might be associated with CKD during inflammatory conditions caused by periodontal disease.