Premium
Levels of serum retinol‐binding protein 4 before and after non‐surgical periodontal treatment in lean and obese subjects: An interventional study
Author(s) -
MartinezHerrera Mayte,
Silvestre Francisco Javier,
SilvestreRangil Javier,
LópezDomènech Sandra,
Bañuls Celia,
Rocha Milagros
Publication year - 2018
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/jcpe.12840
Subject(s) - medicine , periodontitis , chronic periodontitis , retinol binding protein , anthropometry , gastroenterology , dentistry , retinol , vitamin
Aim We aimed to evaluate serum RBP 4 levels before and after periodontal therapy in lean and obese subjects with chronic periodontitis ( CP ) in order to determine its possible association with periodontitis. Materials and Methods This is an interventional study for which a total of 112 lean and 119 obese subjects were recruited. Patients with CP were evaluated before and after three months of non‐surgical periodontal treatment. Periodontal, anthropometric, biochemical parameters and serum levels of TNF ‐α, IL ‐6, hs‐ CRP and RBP 4 were assessed. Results Serum RBP 4 levels were associated with an increased probability of periodontitis ( OR = 1.60; 95% CI : 1.02‐2.50), showing patients with CP to have higher RBP 4 levels than those without CP in both lean and obese populations (3.35 vs 3.06 and 3.74 vs 3.21, respectively). Following periodontal treatment, RBP 4 and TNF ‐α decreased, and all periodontal parameters improved to the same extent in both groups, except for number of teeth with probing depth ( PD ) ≥4 mm, which improved to a less extent in obese than in lean subjects. In the multivariable regression model, the number of teeth with PD ≥4 mm was independently associated with RBP 4 (β = 0.192). Conclusion RBP 4 was associated with chronic periodontitis before and after non‐surgical periodontal treatment.