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Impaired periodontium and temporomandibular joints in tumour necrosis factor‐α transgenic mice
Author(s) -
Dobsak Toni,
Heimel Patrick,
Tangl Stefan,
Schwarze Uwe Y.,
Schett Georg,
Gruber Reinhard
Publication year - 2017
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/jcpe.12799
Subject(s) - periodontal fiber , periodontium , medicine , temporomandibular joint , dentistry , pathology , orthodontics
Aim Tumour necrosis factor ( TNF )‐α is a pathological factor causing the characteristic symptoms of periodontal disease and rheumatoid arthritis. In this study, we describe the phenotypes of human TNF ‐α transgenic mice ( hTNF tg) with respect to their periodontium and the temporomandibular joint ( TMJ ). Material and methods Periodontal structures, TMJ and skull shape of hTNF tg mice and wild‐type ( WT ) littermates were assessed by microcomputed tomography, automated segmentation, geometric morphometrics and histologic ground sections. Results We show that hTNF tg mice have an eroded lamina dura and reduced periodontal ligament space compared to ( WT ) littermates. Transgenic mice further exhibit severe destruction of the TMJ . Geometric morphometrics revealed that hTNF tg mice have a more laterally positioned TMJ with a concomitantly enlarged zygomatic process. Mandibular and maxillary teeth occluded properly. Conclusions Our findings suggest that chronic inflammation in hTNF tg mice causes destructive changes of the periodontium and the TMJ .