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Reduction in bacteremia after brushing with a triclosan/copolymer dentifrice—A randomized clinical study
Author(s) -
Sreenivasan Prem K.,
TischioBereski Deborah,
Fine Daniel H.
Publication year - 2017
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/jcpe.12798
Subject(s) - bacteremia , medicine , dentifrice , toothpaste , triclosan , repeated measures design , dentistry , analysis of variance , gingivitis , randomized controlled trial , tooth brushing , fluoride , antibiotics , toothbrush , biology , microbiology and biotechnology , inorganic chemistry , chemistry , statistics , brush , mathematics , electrical engineering , pathology , engineering
Aim The aims of this study were to; 1) test susceptibility to bacteremia in subjects with moderate gingivitis, and 2) compare the effects of brushing with a fluoride toothpaste (control) as compared to a triclosan/copolymer toothpaste (test) on those susceptible to repeated bacteremia. Materials and Methods One hundred and seven adult subjects were tested for repeated bacteremia after eating a hard apple. Twenty‐nine bacteremia positive subjects were enrolled in a double‐blind cross‐over study designed to analyse the effects of a test toothpaste. After random toothpaste assignment, subjects brushed for 21 days. Following a wash‐out period, subjects completed the study with the alternate toothpaste. Statistical analysis compared bacteremia between groups by analysis of covariance ( ANCOVA ). Results Twenty‐six adult subjects completed the cross‐over study. No statistically significant differences for bacteremia were seen at baseline. Mean bacterial counts at baseline and post‐treatment visits were 45.5 and 10.8 counts versus 48.5 and 38.0 counts, respectively (test vs. control group; significant at p < .05). Significant reductions in blood borne bacteria were seen in the test versus control groups in both cultural and DNA data ( p < .05). Conclusions Thirty percentage of subjects showed repeated bacteremia. Brushing with a triclosan/copolymer dentifrice demonstrated significant reductions in bacteremia as compared to the control toothpaste.