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Periodontal status and serum biomarker levels in HFE haemochromatosis patients. A case‐series study
Author(s) -
Meuric Vincent,
Lainé Fabrice,
Boyer Emile,
Le GallDavid Sandrine,
Oger Emmanuel,
Bourgeois Denis,
Bouchard Philippe,
BardouJacquet Edouard,
Turmel Valérie,
BonnaureMallet Martine,
Deugnier Yves
Publication year - 2017
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/jcpe.12760
Subject(s) - medicine , transferrin saturation , periodontitis , gastroenterology , hemochromatosis , transferrin , odds ratio , serum iron , periodontal examination , chronic periodontitis , biomarker , bleeding on probing , iron deficiency , anemia , chemistry , biochemistry
Abstract Aim To investigate the association between periodontal status and serum biomarkers in patients with HFE haemochromatosis. Material and Methods This clinical case series included 84 HFE ‐C282Y homozygous patients. Periodontal evaluation was performed using clinical attachment level, probing depth, gingival bleeding index, visible plaque index and gingival index. Serum markers of iron metabolism were collected from medical records. The relationship between serum biomarkers of iron burden and the severity of periodontitis was investigated. Results The study population consisted of 47 men and 37 women, routinely treated in the Unit of Hepatology, University Hospital, Rennes. All patients presented with periodontitis (mild: n = 1, moderate: n = 37 and severe: n = 46). There was a positive association between transferrin saturation >45% and the severity of periodontitis (adjusted odds ratio = 5.49, p = .002). Conclusion Severe periodontitis is associated with the severity of iron burden in patients with HFE ‐related hereditary haemochromatosis. Dental examination should be included in the initial assessment of all these patients.