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Association of salivary peroxidase activity and concentration with periodontal health: A validity study
Author(s) -
Memarzadeh Zahedani Maral,
Schwahn Christian,
Baguhl Romy,
Kocher Thomas,
Below Harald,
Welk Alexander
Publication year - 2017
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/jcpe.12754
Subject(s) - peroxidase , periodontitis , saliva , interquartile range , medicine , confidence interval , dentistry , chemistry , biochemistry , enzyme
Aim Whereas the relationship between myeloperoxidase and periodontitis has been widely examined that between salivary peroxidase and periodontitis has received little attention. We examined how periodontitis depends on both salivary peroxidase activity and concentration. Materials and Methods A full mouth, clinical assessment of probing depth was performed in a sample of 46 participants aged 25–54 years. To minimise bias, these data were corrected by data from the general population (Study of Health in Pomerania). Using five repeated measurements of activity and concentration over 1 day, we assessed daily biological variability and increased the reliability of salivary peroxidase measurements. Results Salivary peroxidase activity was associated with probing depth (interquartile range effect = −0.48; robust estimates of 95% confidence interval: −0.90 to −0.31; p = .0052), and its effect was not confounded by salivary peroxidase concentration. In turn, the effect of salivary peroxidase concentration was confounded by salivary peroxidase activity, and it was smaller than that of activity. Conclusions We found an inverse association between salivary peroxidase activity and probing depth. Thus, our results imply that salivary peroxidase activity could be a protective factor against periodontitis. However, large, well‐designed studies are needed to explore the causal mechanisms of this association.