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Saliva and plasma levels of cardiac‐related biomarkers in post‐myocardial infarction patients
Author(s) -
Rathnayake Nilminie,
Buhlin Kåre,
Kjellström Barbro,
Klinge Bjorn,
Löwbeer Christian,
Norhammar Anna,
Rydén Lars,
Sorsa Timo,
Tervahartiala Taina,
Gustafsson Anders
Publication year - 2017
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/jcpe.12740
Subject(s) - saliva , medicine , cystatin c , myocardial infarction , fibrinogen , gdf15 , cardiology , white blood cell , gastroenterology , renal function
Aim To relate cardiac biomarkers, such as cystatin C and growth differentiation factor‐15 ( GDF ‐15) in saliva to myocardial infarction ( MI ) and to periodontal status, and to investigate the relation between salivary and plasma cardiac biomarkers. Materials and Methods Two hundred patients with MI admitted to coronary care units and 200 matched controls without MI were included. Dental examination and collection of blood and saliva samples was performed 6–10 weeks after the MI for patients and in close proximity thereafter for controls. Analysing methods: ARCHITECT i4000 SR , Immulite 2000 XP i or ELISA . Results The mean age was 62 ± 8 years and 84% were male. Total probing pocket depth, fibrinogen, white blood cell counts and HbA1c were higher in patients than controls. GDF ‐15 levels correlated with most of the included clinical variables in both study groups. No correlation was found between plasma and saliva levels of cystatin C or GDF ‐15. Conclusion Salivary cystatin C and GDF ‐15 could not differentiate between MI patients and controls.