Premium
Repair of large saddle defects of the mandibular ridge using dual growth factor release—An experimental pilot study in minipigs
Author(s) -
Tröltzsch Markus,
Klenke Alexander,
Santander Petra,
Kauffmann Philipp,
Tröltzsch Matthias,
Rau Anna,
Brockmeyer Phillip,
Schliephake Henning
Publication year - 2017
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/jcpe.12739
Subject(s) - chemistry , bone formation , dentistry , materials science , andrology , biomedical engineering , medicine , endocrinology
Aim To test the hypothesis that the addition of small amounts of rh VEGF to rh BMP 2 in a polymer carrier can accomplish equivalent repair effect as a reduced dosage of rh BMP 2 compared to rh BMP 2 alone. Materials and Methods Defects were created bilaterally in the mandibles of 18 minipigs. In 12 test animals, defects were filled with 0.5 g particulate PDLLA /Ca CO 3 composite loaded with 400 μg rh BMP 2/50 μg rh VEGF 165 on one side and 800 μg rh BMP 2 on the other. After 4 and 13 weeks, the animals were evaluated each for area of new bone formation (mm²) and bone density (area %). Results Area of newly formed bone was higher in defects with carriers loaded with 400 μg rh BMP 2 50 µg VEGF165 than in defects with 800 μg rh BMP 2 after 4 weeks (11.97 versus 7.97 mm²; p = 0.043) and 13 weeks (72.48 versus 62.2 mm²; p = .028). Defects filled with blank carrier exhibited less bone after 13 weeks (42.75 mm²; p = .039 and .020 respectively). Conclusions Delivery of rh BMP 2 from a polymer carrier can improve repair of large saddle defects of the mandibular ridge. Addition of small amounts of rh VEGF can increase bone formation and at the same time reduce the dosage of rh BMP 2.