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Periodontitis changes renal structures by oxidative stress and lipid peroxidation
Author(s) -
França Luiz Felipe C.,
Vasconcelos Any Carolina C. G.,
Silva Felipe R. P.,
Alves Even H. P.,
Carvalho Joaquina S.,
Lenardo David D.,
Souza Luan K. M.,
Barbosa André L. R.,
Medeiros JandVenes R.,
Oliveira Jefferson S.,
Vasconcelos Daniel F. P.
Publication year - 2017
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/jcpe.12729
Subject(s) - periodontitis , oxidative stress , malondialdehyde , lipid peroxidation , kidney , medicine , myeloperoxidase , pathology , renal function , endocrinology , brush border , chemistry , biochemistry , inflammation , vesicle , membrane
Objective The aim of this study was to investigate whether experimental periodontitis cause changes to the renal tissues and imbalance in oxidative stress in kidneys. Methods Twenty‐two female Wistar rats were separated into two groups: control and periodontitis. We assessed the following parameters: gingival bleeding index ( GBI ), tooth mobility, gum malondialdehyde ( MDA ), myeloperoxidase ( MPO ) activity, probing pocket depth ( PPD ), alveolar bone loss ( ABL ) for periodontal tissues; histomorphometric measures associated with renal corpuscle and histopathological aspects (evaluation of brush border) for kidneys; as also blood and urine biomarkers. Finally, we evaluated renal oxidative stress through glutathione ( GSH ) and MDA respectively. Results With regard to renal histomorphometry, significant differences were observed in all parameters assessed. In relation periodic acid Schiff ( PAS ) staining, disruption was observed of brush border in the periodontitis group in the renal tubules in comparison with the control group. The periodontitis group presented significantly higher MDA and lower GSH concentrations in the kidneys compared with animals without periodontitis. Conclusion The induced periodontitis caused histomorphometric changes in renal tissues as well as disruption of the brush border in renal tubules, alterations associated with increase in oxidative stress in kidneys. However, these alterations were not sufficient to cause differences in the renal function markers.