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Association between diabetes mellitus/hyperglycaemia and peri‐implant diseases: Systematic review and meta‐analysis
Author(s) -
Monje Alberto,
Catena Andres,
Borgnakke Wenche S.
Publication year - 2017
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/jcpe.12724
Subject(s) - mucositis , medicine , diabetes mellitus , peri implantitis , meta analysis , systematic review , dentistry , implant , medline , surgery , endocrinology , chemotherapy , political science , law
Aim This systematic review investigates whether hyperglycaemia/diabetes mellitus is associated with peri‐implant diseases (peri‐implant mucositis and peri‐implantitis). Materials and Methods Electronic and manual literature searching was conducted. An a priori case definition for peri‐implantitis was used as an inclusion criterion to minimize risk of bias. The Newcastle‐Ottawa Scale was used for quality assessment; random effect models were applied; and results were reported according to the PRISMA Statement. Results Twelve studies were eligible for qualitative and seven of them for quantitative analyses. Meta‐analyses detected the risk of peri‐implantitis was about 50% higher in diabetes than in non‐diabetes ( RR = 1.46; 95% CI : 1.21–1.77 and OR = 1.89; 95% CI : 1.31–2.46; z = 5.98; p < .001). Importantly, among non‐smokers, those with hyperglycaemia had 3.39‐fold higher risk for peri‐implantitis compared with normoglycaemia (95% CI : 1.06–10.81). Conversely, the association between diabetes and peri‐implant mucositis was not statistically significant ( RR = 0.92; 95% CI : 0.72–1.16 and OR = 1.06; 95% CI : 0.84–1.27; z = 1.06, p = .29). Conclusions Within its limits that demand great caution when interpreting its findings, this systematic review suggests that diabetes mellitus/hyperglycaemia is associated with greater risk of peri‐implantitis, independently of smoking, but not with peri‐implant mucositis.