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Relationship between renal function and periodontal disease in community‐dwelling elderly women with different genotypes
Author(s) -
Yoshihara Akihiro,
Sugita Noriko,
Iwasaki Masanori,
Wang Yanming,
Miyazaki Hideo,
Yoshie Hiromasa,
Nakamura Kazutoshi
Publication year - 2017
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/jcpe.12708
Subject(s) - medicine , cystatin c , body mass index , renal function , allele , genotype , odds ratio , quartile , endocrinology , logistic regression , gastroenterology , biology , genetics , confidence interval , gene
Objectives The aim of this study was to examine the association between periodontal disease and renal function in elderly women with different genotypes. Material and Methods A total of 332 postmenopausal never‐smoking women were analysed. Poor renal function was defined as serum cystatin C > 0.91 mg/l. Periodontal disease markers such as periodontal inflamed surface area ( PISA ) were evaluated. Selected variables, including PISA quartile, body mass index ( BMI ), HbA1C and age in Arg allele carriers and non‐carriers based on the beta‐3 adrenergic receptor, or between Ala allele carriers and non‐carriers based on peroxisome proliferator‐activated receptor gamma, were analysed using multiple logistic regression analysis. Results The odds ratios of serum cystatin C level and PISA (fourth quartile) were significantly positive for both Arg (2.52; p = 0.035) and Ala allele non‐carriers (2.36; p = 0.021). A significant association was also found between serum cystatin C level and BMI for both Arg (1.18; p = 0.001) and Ala allele non‐carriers (1.12; p = 0.003). Conclusion The results of this study suggest that periodontal inflammation might be associated with renal function. Furthermore, in both the Arg and Ala allele non‐carriers, the associations between BMI and PISA for renal function became stronger.