Premium
Comparative 3D micro‐ CT and 2D histomorphometry analysis of dental implant osseointegration in the maxilla of minipigs
Author(s) -
Bissinger Oliver,
Probst Florian Andreas,
Wolff KlausDietrich,
Jeschke Anke,
Weitz Jochen,
Deppe Herbert,
Kolk Andreas
Publication year - 2017
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/jcpe.12693
Subject(s) - osseointegration , voxel , implant , dental implant , maxilla , bone histomorphometry , histology , nuclear medicine , medicine , dentistry , biomedical engineering , anatomy , pathology , radiology , trabecular bone , surgery , osteoporosis
Abstract Aim The bone implant contact ( BIC ) has traditionally been evaluated with histological methods. Thereupon, strong correlations of two‐dimensional (2D) BIC have been detected between μ CT and destructive histology. However, due to the high intra‐sample variability in BIC values, one histological slice is not sufficient to represent 3D BIC . Therefore, our aim has been to correlate the averaged values of 3–4 histological sections to 3D μ CT . Material and Methods Fifty‐four implants inserted into the maxilla of 14 minipigs were evaluated. Two different time points were selected to assess the 3D BIC (distance to implant: 2–5 voxels), an inner ring (6–30 voxels) and an outer ring (55–100 voxels) using μ CT (voxel size: 10 μ m) and to correlate the values to histomorphometry. Results Strong correlations ( p < 0.0001; 28 days, 56 days, total) were seen between μ CT and histomorphometry concerning BIC ( r = 0.84, r = 0.85, r = 0.83), the inner ring ( r = 0.87, r = 0.87, r = 0.88) and the outer ring ( r = 0.85, r = 0.85, r = 0.88). Closer to the implant, μ CT values were higher compared with histomorphometry. Conclusion Although 3–4 histological slices per implant seem to predict the 3D BIC , μ CT might be advantageous because of its non‐destructive 3D character. The healing time may not impact on the comparability.