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Gingivitis and lifestyle influences on high‐sensitivity C‐reactive protein and interleukin 6 in adolescents
Author(s) -
Pitchika Vinay,
Thiering Elisabeth,
Metz Isabel,
Rothmaier Katrin,
Willenberg Anja,
Hickel Reinhard,
Standl Marie,
Kocher Thomas,
Heinrich Joachim,
Kühnisch Jan
Publication year - 2017
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/jcpe.12690
Subject(s) - gingivitis , medicine , overweight , c reactive protein , body mass index , confounding , logistic regression , obesity , oral hygiene , dentistry , inflammation
Aim This cross‐sectional study was repeated at two time points and investigated the influence of gingivitis, smoking and body mass index (BMI) on the systemic inflammatory markers high‐sensitivity C‐reactive protein (hs‐CRP) and interleukin 6 (IL6) in 10‐ and 15‐year‐olds. Materials and Methods The study sample of two birth cohorts, i.e. GINIplus and LISAplus, from the Munich centre consisted of 806 and 846 subjects who were evaluated at 10‐ and 15‐year follow‐ups respectively. Children and their parents completed questionnaires on participant‐related lifestyle information. Gingivitis was measured at the sextant level using a simplified sulcus‐bleeding index. Serum hs‐CRP and IL6 levels were obtained from blood samples. Multiple logistic regressions adjusting for lifestyle‐related factors and other confounders were performed to assess associations between the specified variables. Results There were no associations between gingivitis and the inflammatory markers hs‐CRP and IL6 in 10‐year‐olds. In 15‐year‐olds, gingivitis (aOR: 2.17; 95% CI: 1.25–3.77); daily smoking (aOR: 6.27; 95% CI: 1.39–28.39); and being overweight/obese (aOR: 4.95; 95% CI: 0.73–33.68) were identified as significantly influencing factors for elevated hs‐CRP values. Oral hygiene did not influence hs‐CRP. Conclusion In this study, hs‐CRP was positively associated with gingivitis, smoking daily and overweight/obesity among 15‐year‐olds.