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Aim  To analyse the regenerative potential of leucocyte‐ and platelet‐rich fibrin (L‐ PRF ) during periodontal surgery.    Materials and Methods  An electronic and hand search were conducted in three databases. Only randomized clinical trials were selected and no follow‐up limitation was applied. Pocket depth ( PD ), clinical attachment level ( CAL ), bone fill, keratinized tissue width ( KTW ), recession reduction and root coverage (%) were considered as outcome. When possible, meta‐analysis was performed.    Results  Twenty‐four articles fulfilled the inclusion and exclusion criteria. Three subgroups were created: intra‐bony defects ( IBD s), furcation defects and periodontal plastic surgery. Meta‐analysis was performed in all the subgroups. Significant  PD  reduction (1.1 ± 0.5 mm,  p  < 0.001),  CAL  gain (1.2 ± 0.6 mm,  p  < 0.001) and bone fill (1.7 ± 0.7 mm,  p  < 0.001) were found when comparing L‐ PRF  to open flap debridement ( OFD ) in  IBD s. For furcation defects, significant  PD  reduction (1.9 ± 1.5 mm,  p  = 0.01),  CAL  gain (1.3 ± 0.4 mm,  p  < 0.001) and bone fill (1.5 ± 0.3 mm,  p  < 0.001) were reported when comparing L‐ PRF  to  OFD . When L‐ PRF  was compared to a connective tissue graft, similar outcomes were recorded for  PD  reduction (0.2 ± 0.3 mm,  p  > 0.05),  CAL  gain (0.2 ± 0.5 mm,  p  > 0.05),  KTW  (0.3 ± 0.4 mm,  p  > 0.05) and recession reduction (0.2 ± 0.3 mm,  p  > 0.05).    Conclusions  L‐ PRF  enhances periodontal wound healing.

journal of clinical periodontology

Regenerative potential of leucocyte‐ and platelet‐rich fibrin. Part A: intra‐bony defects, furcation defects and periodontal plastic surgery. A systematic review and meta‐analysis