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Regenerative potential of leucocyte‐ and platelet‐rich fibrin. Part A: intra‐bony defects, furcation defects and periodontal plastic surgery. A systematic review and meta‐analysis
Author(s) -
Castro Ana B.,
Meschi Nastaran,
Temmerman Andy,
Pinto Nelson,
Lambrechts Paul,
Teughels Wim,
Quirynen Marc
Publication year - 2017
Publication title -
journal of clinical periodontology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.456
H-Index - 151
eISSN - 1600-051X
pISSN - 0303-6979
DOI - 10.1111/jcpe.12643
Subject(s) - platelet rich fibrin , gingival recession , medicine , dentistry , fibrin , furcation defect , connective tissue , hard tissue , reduction (mathematics) , pathology , molar , geometry , mathematics , immunology
Aim To analyse the regenerative potential of leucocyte‐ and platelet‐rich fibrin (L‐ PRF ) during periodontal surgery. Materials and Methods An electronic and hand search were conducted in three databases. Only randomized clinical trials were selected and no follow‐up limitation was applied. Pocket depth ( PD ), clinical attachment level ( CAL ), bone fill, keratinized tissue width ( KTW ), recession reduction and root coverage (%) were considered as outcome. When possible, meta‐analysis was performed. Results Twenty‐four articles fulfilled the inclusion and exclusion criteria. Three subgroups were created: intra‐bony defects ( IBD s), furcation defects and periodontal plastic surgery. Meta‐analysis was performed in all the subgroups. Significant PD reduction (1.1 ± 0.5 mm, p < 0.001), CAL gain (1.2 ± 0.6 mm, p < 0.001) and bone fill (1.7 ± 0.7 mm, p < 0.001) were found when comparing L‐ PRF to open flap debridement ( OFD ) in IBD s. For furcation defects, significant PD reduction (1.9 ± 1.5 mm, p = 0.01), CAL gain (1.3 ± 0.4 mm, p < 0.001) and bone fill (1.5 ± 0.3 mm, p < 0.001) were reported when comparing L‐ PRF to OFD . When L‐ PRF was compared to a connective tissue graft, similar outcomes were recorded for PD reduction (0.2 ± 0.3 mm, p > 0.05), CAL gain (0.2 ± 0.5 mm, p > 0.05), KTW (0.3 ± 0.4 mm, p > 0.05) and recession reduction (0.2 ± 0.3 mm, p > 0.05). Conclusions L‐ PRF enhances periodontal wound healing.